Low-dose Allergy (LDA) Therapy and Low-dose Immunotherapy (LDI)


Low-dose allergy (LDA) therapy and low-dose immunotherapy (LDI) are safe and effective treatment options for a variety of symptoms caused by food and environmental allergies. In addition, infections can trigger immune dysfunction and autoimmune diseases. Allergies and autoimmune conditions have been on the rise for the past 30 years.

How does LDA and LDI Work

LDA and LDI use extremely low doses of antigens in conjunction with the enzyme beta glucuronidase to down regulate an inappropriate immune response. This is also known as increasing immune “tolerance.” LDA and LDI are better tolerated than conventional allergy therapy, as well as being more convenient and effective. Conventional treatment with escalating doses of allergens often require twice weekly injections for 4 to 6 months, then continued at extended ongoing intervals. Low-dose therapy injections are only given every 7 weeks, and frequency is reduced over time as a patient’s symptoms improve. Contrary to conventional allergy injections, LDA and LDI doses are much lower, and there has never been a reported case of anaphylaxis.

Conditions Treated

LDA and LDI treat a wide range of immune dysfunction including food and inhalant allergies, chemical sensitivity, autoimmune conditions and symptoms triggered by infections such as Lyme disease.

LDA and LDI is effective at treating immune reactions including:

  • Infection – Lyme disease, bartonella, babesia, erlichia, mycoplasma, Epstein-Barr virus (EBV), cytomegalovirus (CMV), HHV-6, herpes, shingles
  • Digestive – food, allergies IBS, diarrhea, Crohn’s disease, ulcerative colitis, Celiac disease
  • Environmental – grasses, pollen, mold, pet dander, dust; multiple chemical sensitivity
  • Inhalant – asthma, hay fever (seasonal allergies)
  • Skin – eczema, acne, psoriasis, hives, vitiligo, alopecia
  • Autoimmune – inflammatory and rheumatoid arthritis, autoimmune thyroiditis, ankylosing spondylitis
  • Neurological – headaches or migraines related to food
  • Conditions such as chronic fatigue syndrome, fibromyalgia, symptoms from candida/yeast and inflammatory arthritis

Dr. Maderis trained in LDA and LDI therapy, and uses it to treat a variety of conditions. Call Marin Natural Medicine Clinic if you would like to schedule an appointment for LDA and/or LDI.